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Document type:
journal article 
Author(s):
Paepke, S; Blohmer, JU; Warm, M; Ohlinger, R; Kiechle, M 
Title:
Zoledronic Acid in Adjuvant Therapy of Receptor Negative Early Breast Cancer - Rationale and First Experience in Individual Therapy Strategy 
Abstract:
Previous studies have already shown a survival benefit in sub groups of metastatic breast cancer treated with bisphosphonates. Zoledronate given monthly to patients with metastatic disease to the bones showed a reduction in mortality of 32% [1]. Conceivable mechanisms include changes in the microenvironment of tumor cells, induction of apoptotic pathways, reduction of angiogenesis and cell adhesion [2-7]. Moreover, zoledronate interferes with the interaction between tumor cells and the bone marr...    »
 
Journal title abbreviation:
Geburtshilfe Frauenheilkd 
Year:
2011 
Journal volume:
71 
Journal issue:
Pages contribution:
135-139 
Language:
de 
Print-ISSN:
0016-5751 
TUM Institution:
Frauenklinik und Poliklinik