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Dokumenttyp:
journal article 
Autor(en):
Foekens, JA; Atkins, D; Zhang, Y; Sweep, FC; Harbeck, N; Paradiso, A; Cufer, T; Sieuwerts, AM; Talantov, D; Span, PN; Tjan-Heijnen, VC; Zito, AF; Specht, K; Hoefler, H; Golouh, R; Schittulli, F; Schmitt, M; Beex, LV; Klijn, JG; Wang, Y 
Titel:
Multicenter validation of a gene expression-based prognostic signature in lymph node-negative primary breast cancer. 
Abstract:
PURPOSE: We previously identified in a single-center study a 76-gene prognostic signature for lymph node-negative (LNN) breast cancer patients. The aim of this study was to validate this gene signature in an independent more diverse population of LNN patients from multiple institutions. PATIENTS AND METHODS: Using custom-designed DNA chips we analyzed the expression of the 76 genes in RNA of frozen tumor samples from 180 LNN patients who did not receive adjuvant systemic treatment. RESULTS: In t...    »
 
Zeitschriftentitel:
J Clin Oncol 
Jahr:
2006 
Band / Volume:
24 
Heft / Issue:
11 
Seitenangaben Beitrag:
1665-71 
Sprache:
eng 
Print-ISSN:
0732-183X 
TUM Einrichtung:
Frauenklinik und Poliklinik; r Allgemeine Pathologie und pathologische Anatomie