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- Dokumenttyp:
- Clinical Trial; Clinical Trial, Phase II; Controlled Clinical Trial; Journal Article; Multicenter Study; Article
- Autor(en):
- Kümmel, S; Thomas, A; Paepke, S; Schwarz, M; Heinrich, G; Wetzel, A; Elling, D; Kohls, A; Lichtenegger, W; Blohmer, JU
- Titel:
- Primary systemic chemotherapy with sequential, dose-dense epirubicin and docetaxel for inoperable, locally advanced inflammatory breast cancer: a phase II study.
- Abstract:
- Sequential, dose-dense epirubicin plus docetaxel was evaluated as primary systemic therapy for women with inoperable, locally advanced breast cancer (LABC) or inflammatory breast cancer (IBC). Patients (LABC n=27; IBC n=7) received 3 cycles of epirubicin 120 mg/m2 every 2 weeks followed by 3 cycles of docetaxel 100 mg/m2 every 2 weeks, with granulocyte colony-stimulating factor. Grade 3-4 toxicities were observed in 21 of 195 cycles (10.8%). Grade 3 anemia and leukopenia each occurred in 1% of cycles. Following chemotherapy, all patients underwent surgery. Eight patients (23.5%) had a clinical complete response and 15 (44.1%) had a partial response. In patients with IBC, median skin thickness decreased from 5.85 mm (range: 3.1-6.2 mm) to 4 mm (range: 2.7-5.1 mm) (p<0.005). Sequential, dose-dense epirubicin plus docetaxel achieved a high response rate among patients with LABC or IBC with only moderate toxicity.
- Zeitschriftentitel:
- Acta Oncol
- Jahr:
- 2005
- Band / Volume:
- 44
- Heft / Issue:
- 3
- Seitenangaben Beitrag:
- 248-54
- Sprache:
- eng
- Volltext / DOI:
- doi:10.1080/02841860510029725
- PubMed:
- http://view.ncbi.nlm.nih.gov/pubmed/16076697
- Print-ISSN:
- 0284-186X
- TUM Einrichtung:
- Frauenklinik und Poliklinik
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