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Dokumenttyp:
journal article 
Autor(en):
Harbeck, N; Kates, RE; Gauger, K; Willems, A; Kiechle, M; Magdolen, V; Schmitt, M 
Titel:
Urokinase-type plasminogen activator (uPA) and its inhibitor PAI-I: novel tumor-derived factors with a high prognostic and predictive impact in breast cancer. 
Abstract:
Urokinase-type plasminogen activator (uPA) and its inhibitor, PAI-I, play a key role in tumor invasion and metastasis. They were the first novel tumor biological factors to be validated at the highest level of evidence (LOE I) regarding their clinical utility in breast cancer. Their antigen levels are determined in tumor tissue extracts by standardized, quality-assured immunometric assays (ELISA). Since the late 1980s, numerous independent studies have demonstrated that patients with low levels...    »
 
Zeitschriftentitel:
Thromb Haemost 
Jahr:
2004 
Band / Volume:
91 
Heft / Issue:
Seitenangaben Beitrag:
450-6 
Sprache:
eng 
Print-ISSN:
0340-6245 
TUM Einrichtung:
Frauenklinik und Poliklinik