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Dokumenttyp:
journal article 
Autor(en):
Glockzin, G; Mantwill, K; Jurchott, K; Bernshausen, A; Ladhoff, A; Royer, HD; Gansbacher, B; Holm, PS 
Titel:
Characterization of the recombinant adenovirus vector AdYB-1: implications for oncolytic vector development. 
Abstract:
Conditionally replicating adenoviruses are a promising new modality for the treatment of cancer. However, early clinical trials demonstrate that the efficacy of current vectors is limited. Interestingly, DNA replication and production of viral particles do not always correlate with virus-mediated cell lysis and virus release depending on the vector utilized for infection. However, we have previously reported that nuclear accumulation of the human transcription factor YB-1 by regulating the adeno...    »
 
Zeitschriftentitel:
J Virol 
Jahr:
2006 
Band / Volume:
80 
Heft / Issue:
Seitenangaben Beitrag:
3904-11 
Sprache:
eng 
Print-ISSN:
0022-538X 
TUM Einrichtung:
r experimentelle Onkologie und Therapieforschung