Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
Banke, IJ; Arlt, MJ; Mueller, MM; Sperl, S; Stemberger, A; Stürzebecher, J; Amirkhosravi, A; Moroder, L; Krüger, A 
Titel:
Effective inhibition of experimental metastasis and prolongation of survival in mice by a potent factor Xa-specific synthetic serine protease inhibitor with weak anticoagulant activity. 
Abstract:
Clinical and experimental evidence suggests that the blood coagulation system is involved in the dissemination of malignant tumors. Consequently, anticoagulant agents have been tested as metastasis suppressors in experimental models. Recently, we have found a close correlation between factor Xa (FXa)-specificity of a series of synthetic serine protease inhibitors and their anti-metastatic potential in a murine T-cell lymphoma metastasis model. Interference of such inhibitors with blood-coagulati...    »
 
Zeitschriftentitel:
Thromb Haemost 
Jahr:
2005 
Band / Volume:
94 
Heft / Issue:
Seitenangaben Beitrag:
1084-93 
Sprache:
eng 
Print-ISSN:
0340-6245 
TUM Einrichtung:
r experimentelle Onkologie und Therapieforschung