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Dokumenttyp:
journal article 
Autor(en):
Merl, S; Michaelis, C; Jaschke, B; Vorpahl, M; Seidl, S; Wessely, R 
Titel:
Targeting 2A protease by RNA interference attenuates coxsackieviral cytopathogenicity and promotes survival in highly susceptible mice. 
Abstract:
BACKGROUND: Enteroviridae such as coxsackievirus B3 (CVB3) are important infectious agents involved in viral heart disease, hepatitis, and pancreatitis, but no specific antiviral therapy is available. METHODS AND RESULTS: The aim of the present study was to evaluate the impact of RNA interference on viral replication, cytopathogenicity, and survival. Small interfering RNA (siRNA) molecules were designed against the viral 2A region (siRNA-2A), which is considered to be highly conserved and essent...    »
 
Zeitschriftentitel:
Circulation 
Jahr:
2005 
Band / Volume:
111 
Heft / Issue:
13 
Seitenangaben Beitrag:
1583-92 
Sprache:
eng 
Print-ISSN:
0009-7322 
TUM Einrichtung:
I. Medizinische Klinik und Poliklinik; r experimentelle Onkologie und Therapieforschung; r Allgemeine Pathologie und pathologische Anatomie