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Document type:
journal article 
Author(s):
Retz, M; Sidhu, SS; Lehmann, J; Tamamura, H; Fujii, N; Basbaum, C 
Title:
New HIV-drug inhibits in vitro bladder cancer migration and invasion. 
Abstract:
OBJECTIVE: The CXCR4/CXCL12 axis appears crucial in the metastasis of bladder cancer. Our aim was to evaluate the potency of the CXCR4 antagonist, 4F-benzoyl-TE14011 (4F-bTE), as an anti-metastatic drug in this disease. In this study, we assessed the ability of 4F-bTE to inhibit tumor cell motility, invasion through extracellular matrix (ECM), matrix metalloproteinase (MMP) secretion and cytoskeletal responses to chemokine. METHODS: To assess the degree to which cells could migrate and invade EC...    »
 
Journal title abbreviation:
Eur Urol 
Year:
2005 
Journal volume:
48 
Journal issue:
Pages contribution:
1025-30 
Language:
eng 
Print-ISSN:
0302-2838 
TUM Institution:
Urologische Klinik und Poliklinik