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Document type:
journal article 
Author(s):
Holm, PS; Lage, H; Bergmann, S; Jürchott, K; Glockzin, G; Bernshausen, A; Mantwill, K; Ladhoff, A; Wichert, A; Mymryk, JS; Ritter, T; Dietel, M; Gänsbacher, B; Royer, HD 
Title:
Multidrug-resistant cancer cells facilitate E1-independent adenoviral replication: impact for cancer gene therapy. 
Abstract:
Resistance to chemotherapy is responsible for a failure of current treatment regimens in cancer patients. We have reported previously that the Y-box protein YB-1 regulates expression of the P-glycoprotein gene mdr1, which plays a major role in the development of a multidrug resistant-tumor phenotype. YB-1 predicts drug resistance and patient outcome in breast cancer. Thus, YB-1 is a promising target for new therapeutic approaches to defeat multidrug resistance. In drug-resistant cancer cells and...    »
 
Journal title abbreviation:
Cancer Res 
Year:
2004 
Journal volume:
64 
Journal issue:
Pages contribution:
322-8 
Language:
eng 
Print-ISSN:
0008-5472 
TUM Institution:
Institut für experimentelle Onkologie und Therapieforschung