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Document type:
journal article 
Author(s):
Schweinitz, A; Steinmetzer, T; Banke, IJ; Arlt, MJ; Stürzebecher, A; Schuster, O; Geissler, A; Giersiefen, H; Zeslawska, E; Jacob, U; Krüger, A; Stürzebecher, J 
Title:
Design of novel and selective inhibitors of urokinase-type plasminogen activator with improved pharmacokinetic properties for use as antimetastatic agents. 
Abstract:
The serine protease urokinase-type plasminogen activator (uPA) interacts with a specific receptor (uPAR) on the surface of various cell types, including tumor cells, and plays a crucial role in pericellular proteolysis. High levels of uPA and uPAR often correlate with poor prognosis of cancer patients. Therefore, the specific inhibition of uPA with small molecule active-site inhibitors is one strategy to decrease the invasive and metastatic activity of tumor cells. We have developed a series of...    »
 
Journal title abbreviation:
J Biol Chem 
Year:
2004 
Journal volume:
279 
Journal issue:
32 
Pages contribution:
33613-22 
Language:
eng 
Print-ISSN:
0021-9258 
TUM Institution:
Institut für experimentelle Onkologie und Therapieforschung