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Document type:
journal article 
Author(s):
Gerhard, MC; Zantl, N; Weirich, G; Schliep, S; Seiffert, B; Häcker, G 
Title:
Functional evaluation of the apoptosome in renal cell carcinoma. 
Abstract:
Renal cell carcinoma (RCC) responds very poorly to chemo- or radiotherapy. Renal cell carcinoma cell lines have been described to be resistant to apoptosis-inducing stimuli and to lack caspase expression. Here, we provide a structural and functional assessment of the apoptosome, the central caspase-activating signalling complex and a candidate for apoptosis-inactivating mutations. Cells from RCC cell lines and clinical samples isolated from RCC patients were included. Apoptosome function was mea...    »
 
Journal title abbreviation:
Br J Cancer 
Year:
2003 
Journal volume:
89 
Journal issue:
11 
Pages contribution:
2147-54 
Language:
eng 
Print-ISSN:
0007-0920 
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene ; Urologische Klinik und Poliklinik ; Institut für Allgemeine Pathologie und pathologische Anatomie