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Dokumenttyp:
journal article 
Autor(en):
Reuning, U; Sperl, S; Kopitz, C; Kessler, H; Krüger, A; Schmitt, M; Magdolen, V 
Titel:
Urokinase-type plasminogen activator (uPA) and its receptor (uPAR): development of antagonists of uPA/uPAR interaction and their effects in vitro and in vivo. 
Abstract:
In cancer, increased levels of the tumor-associated serine protease uPA (urokinase-type plasminogen activator) and its receptor uPAR (CD87) are linked to tumor progression, metastasis, and shortened survival in patients afflicted with this disease. Strong clinical and experimental evidence has accumulated that the cell surface interaction of uPA with uPAR facilitates extravasation and intravasation of cancer cells by regulating local proteolysis and attachment of the cells to components of the e...    »
 
Zeitschriftentitel:
Curr Pharm Des 
Jahr:
2003 
Band / Volume:
Heft / Issue:
19 
Seitenangaben Beitrag:
1529-43 
Sprache:
eng 
Print-ISSN:
1381-6128 
TUM Einrichtung:
Frauenklinik und Poliklinik; r experimentelle Onkologie und Therapieforschung