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Dokumenttyp:
journal article 
Autor(en):
van Harmelen, V; Skurk, T; Röhrig, K; Hauner, H 
Titel:
HMG-CoA reductase inhibitor cerivastatin inhibits interleukin-6 expression and secretion in human adipocytes. 
Abstract:
Human adipose tissue is a main contributor to plasma levels of pro-inflammatory cytokine IL-6. How IL-6 expression is regulated in adipocytes remains unclear. In the current study, we investigated the effect of the HMG-CoA reductase inhibitor, cerivastatin, on the production of IL-6 from cultured human adipocytes. Cerivastatin reduced both IL-6 mRNA and secretion in a dose- and time-dependent manner. The inhibitory effect on IL-6 mRNA was prevented by the intermediates of the cholesterol synthes...    »
 
Zeitschriftentitel:
Horm Metab Res 
Jahr:
2003 
Band / Volume:
35 
Heft / Issue:
Seitenangaben Beitrag:
466-70 
Sprache:
eng 
Print-ISSN:
0018-5043 
TUM Einrichtung:
hrungsmedizin