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Document type:
journal article 
Author(s):
Beyerle, A; Braun, A; Merkel, O; Koch, F; Kissel, T; Stoeger, T 
Title:
Comparative in vivo study of poly(ethylene imine)/siRNA complexes for pulmonary delivery in mice. 
Abstract:
Pulmonary siRNA delivery offers a new way to treat various lung diseases. Poly(ethylene imines) (PEIs) are promising cationic nanocarriers and various modifications are still under investigations to improve their cytotoxicity and efficacy for siRNA delivery. In this study, we analyzed two different types of PEI-based nanocomplexes in mice after intratracheal administration regarding their toxicity and efficacy in the lungs. Ubiquitously enhanced green fluorescent protein (EGFP) expressing transg...    »
 
Journal title abbreviation:
J Control Release 
Year:
2011 
Journal volume:
151 
Journal issue:
Pages contribution:
51-6 
Language:
eng 
Print-ISSN:
0168-3659 
TUM Institution:
Institut für Molekulare Allergologie und Umweltforschung