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Document type:
journal article 
Author(s):
Soligo, M; Camperio, C; Caristi, S; Scottà, C; Del Porto, P; Costanzo, A; Mantel, PY; Schmidt-Weber, CB; Piccolella, E 
Title:
CD28 costimulation regulates FOXP3 in a RelA/NF-?B-dependent mechanism. 
Abstract:
The molecular mechanisms whereby CD28 alone or associated with TCR can regulate FOXP3 expression are not understood, although the importance of CD28 as a pivotal regulator of CD4(+) CD25(+) FOXP3(+) T cells is well recognized. We previously demonstrated that unique CD28-induced, NF-?B-dependent signals were sufficient to activate FOXP3 transcription in human CD4(+) CD25(-) T cells; however, the exact mechanisms are currently unknown. In this study, we have identified novel ?B-binding sites on F...    »
 
Journal title abbreviation:
Eur J Immunol 
Year:
2011 
Journal volume:
41 
Journal issue:
Pages contribution:
503-13 
Language:
eng 
Print-ISSN:
0014-2980 
TUM Institution:
Institut für Molekulare Allergologie und Umweltforschung