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Document type:
journal article 
Author(s):
Vale-Pereira, S; Todo-Bom, A; Geraldes, L; Schmidt-Weber, C; Akdis, CA; Mota-Pinto, A 
Title:
FoxP3, GATA-3 and T-bet expression in elderly asthma. 
Abstract:
Asthma is a chronic inflammatory disorder in which Th2, Th1 and suppressive T cells (Tregs) play a role. The transcription factor FoxP3 plays a role in Treg differentiation while T-bet is important for Th1 and GATA-3 for Th2 differentiation from naïve T cells. Recent data show that age-related deregulation of Treg cells is a mechanism of senescence affecting several chronic diseases. It is crucial to understand the behaviour of these cell populations in asthma for elderly patients.To evaluate Fo...    »
 
Journal title abbreviation:
Clin Exp Allergy 
Year:
2011 
Journal volume:
41 
Journal issue:
Pages contribution:
490-6 
Language:
eng 
Print-ISSN:
0954-7894 
TUM Institution:
Institut für Molekulare Allergologie und Umweltforschung