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Dokumenttyp:
journal article 
Autor(en):
Schober, W; Luch, A; Soballa, VJ; Raab, G; Stegeman, JJ; Doehmer, J; Jacob, J; Seidel, A 
Titel:
On the species-specific biotransformation of dibenzo[a,l]pyrene. 
Abstract:
We were aimed at investigating the activation of the carcinogenic polycyclic aromatic hydrocarbon (PAH) dibenzo[a,l]pyrene (DB[a,l]P) in Chinese hamster V79 cells that express single human, rat or fish cytochrome P450 (CYP) enzymes. DB[a,l]P is detectable in environmental samples and has been characterized as the most potent carcinogenic species among all PAHs as yet tested in rodent bioassays. Metabolite profiles and metabolite-dependent cytotoxic and clastogenic activities were monitored. The...    »
 
Zeitschriftentitel:
Chem Biol Interact 
Jahr:
2006 
Band / Volume:
161 
Heft / Issue:
Seitenangaben Beitrag:
37-48 
Sprache:
eng 
Print-ISSN:
0009-2797 
TUM Einrichtung:
r Dermatologie und Allergologie