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Document type:
journal article 
Author(s):
Schober, W; Luch, A; Soballa, VJ; Raab, G; Stegeman, JJ; Doehmer, J; Jacob, J; Seidel, A 
Title:
On the species-specific biotransformation of dibenzo[a,l]pyrene. 
Abstract:
We were aimed at investigating the activation of the carcinogenic polycyclic aromatic hydrocarbon (PAH) dibenzo[a,l]pyrene (DB[a,l]P) in Chinese hamster V79 cells that express single human, rat or fish cytochrome P450 (CYP) enzymes. DB[a,l]P is detectable in environmental samples and has been characterized as the most potent carcinogenic species among all PAHs as yet tested in rodent bioassays. Metabolite profiles and metabolite-dependent cytotoxic and clastogenic activities were monitored. The...    »
 
Journal title abbreviation:
Chem Biol Interact 
Year:
2006 
Journal volume:
161 
Journal issue:
Pages contribution:
37-48 
Language:
eng 
Print-ISSN:
0009-2797 
TUM Institution:
Klinik und Poliklinik für Dermatologie und Allergologie