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Dokumenttyp:
journal article 
Autor(en):
Braun-Falco, M; Eisenried, A; Büning, H; Ring, J 
Titel:
Recombinant adeno-associated virus type 2-mediated gene transfer into human keratinocytes is influenced by both the ubiquitin/proteasome pathway and epidermal growth factor receptor tyrosine kinase. 
Abstract:
Efficient gene delivery into keratinocytes is a prerequisite for successful skin gene therapy. Vectors based on recombinant adeno-associated virus type 2 (rAAV-2) offer several promising features that make them attractive for cutaneous applications. However, highly efficient gene delivery may be hampered by different cellular factors, including lack of viral receptors, impairment of cytoplasmic trafficking or limitations in viral second-strand synthesis. This study was undertaken to find factors...    »
 
Zeitschriftentitel:
Arch Dermatol Res 
Jahr:
2005 
Band / Volume:
296 
Heft / Issue:
11 
Seitenangaben Beitrag:
528-35 
Sprache:
eng 
Print-ISSN:
0340-3696 
TUM Einrichtung:
r Dermatologie und Allergologie