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Document type:
journal article 
Author(s):
Hofer, A; Berg, D; Asmus, F; Niwar, M; Ransmayr, G; Riemenschneider, M; Bonelli, SB; Steffelbauer, M; Ceballos-Baumann, A; Haussermann, P; Behnke, S; Krüger, R; Prestel, J; Sharma, M; Zimprich, A; Riess, O; Gasser, T 
Title:
The role of alpha-synuclein gene multiplications in early-onset Parkinson's disease and dementia with Lewy bodies. 
Abstract:
Background: A triplication of the alpha-synuclein gene was found to cause autosomal dominant Lewy body disease in two distinct families. Method: We searched for alterations of alpha-synuclein gene dosage and analysed the entire coding region for point mutations in 54 dementia with Lewy body disease (DLB) and in 103 young onset Parkinson's disease (PD) patients from Central Europe. Results: We could not detect any quantitative alterations in the gene dosage of alpha-synuclein. Mutational screenin...    »
 
Journal title abbreviation:
J Neural Transm 
Year:
2005 
Journal volume:
112 
Journal issue:
Pages contribution:
1249-54 
Language:
eng 
Print-ISSN:
0300-9564 
TUM Institution:
Klinik und Poliklinik für Psychiatrie und Psychotherapie ; Neurologische Klinik und Poliklinik