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Dokumenttyp:
journal article 
Autor(en):
Pfister, H; Ollert, M; Fröhlich, LF; Quintanilla-Martinez, L; Colby, TV; Specks, U; Jenne, DE 
Titel:
Antineutrophil cytoplasmic autoantibodies against the murine homolog of proteinase 3 (Wegener autoantigen) are pathogenic in vivo. 
Abstract:
Antineutrophil cytoplasmic autoantibodies (ANCAs) recognizing human proteinase 3 of neutrophil granules are a diagnostic hallmark of Wegener granulomatosis, an autoimmune systemic vasculitis with predilection for the respiratory tract and kidneys. In vitro experiments have implicated several mechanisms by which ANCAs may lead to tissue injury. However, little is known about the pathogenic significance of proteinase 3-specific antibodies in vivo. In vivo models for ANCA-mediated proinflammatory e...    »
 
Zeitschriftentitel:
Blood 
Jahr:
2004 
Band / Volume:
104 
Heft / Issue:
Seitenangaben Beitrag:
1411-8 
Sprache:
eng 
Print-ISSN:
0006-4971 
TUM Einrichtung:
r Dermatologie und Allergologie