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Document type:
journal article 
Author(s):
Weidinger, S; Klopp, N; Wagenpfeil, S; Rümmler, L; Schedel, M; Kabesch, M; Schäfer, T; Darsow, U; Jakob, T; Behrendt, H; Wichmann, HE; Ring, J; Illig, T 
Title:
Association of a STAT 6 haplotype with elevated serum IgE levels in a population based cohort of white adults. 
Abstract:
BACKGROUND: Several studies have shown linkage of chromosome 12q 13-24 with atopy related phenotypes. Among candidate genes in this region is STAT6 (signal transducer and activator of transcription), which is essential for Th2 cell differentiation, recruitment, and effector function. METHODS: We evaluated six polymorphisms of STAT6 for evidence of associations with serum IgE levels and atopic diseases in a population based cross sectional cohort of 1407 German adults. Genotyping was performed us...    »
 
Journal title abbreviation:
J Med Genet 
Year:
2004 
Journal volume:
41 
Journal issue:
Pages contribution:
658-63 
Language:
eng 
Print-ISSN:
0022-2593 
TUM Institution:
Klinik und Poliklinik für Dermatologie und Allergologie ; Institut für Medizinische Statistik und Epidemiologie