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Document type:
journal article 
Author(s):
Hauschild, A; Weichenthal, M; Balda, BR; Becker, JC; Wolff, HH; Tilgen, W; Schulte, KW; Ring, J; Schadendorf, D; Lischner, S; Burg, G; Dummer, R 
Title:
Prospective randomized trial of interferon alfa-2b and interleukin-2 as adjuvant treatment for resected intermediate- and high-risk primary melanoma without clinically detectable node metastasis. 
Abstract:
PURPOSE: Low-dose interferon alfa (IFNalpha) has been shown to have limited effects in the adjuvant treatment of patients with intermediate- and high-risk primary melanoma. We hypothesized that a combination regimen with low-dose interleukin-2 (IL-2) may improve survival prospects in these patients. PATIENTS AND METHODS: After wide excision of primary melanoma without clinically detectable lymph node metastasis (pT3 to 4, cN0, M0), 225 patients from 10 participating centers were randomly assigne...    »
 
Journal title abbreviation:
J Clin Oncol 
Year:
2003 
Journal volume:
21 
Journal issue:
15 
Pages contribution:
2883-8 
Language:
eng 
Print-ISSN:
0732-183X 
TUM Institution:
r Dermatologie und Allergologie