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Dokumenttyp:
journal article 
Autor(en):
Weighardt, H; Jusek, G; Mages, J; Lang, R; Hoebe, K; Beutler, B; Holzmann, B 
Titel:
Identification of a TLR4- and TRIF-dependent activation program of dendritic cells. 
Abstract:
Dendritic cell activation by Toll-like receptors (TLR) is crucial for the generation of protective immune responses. In addition to the common myeloid differentiation factor 88 (MyD88)-dependent signaling pathway, TLR4 engages the adaptor protein Toll/IL-1 receptor (TIR)-domain-containing adaptor inducing IFN-beta (TRIF), leading to interferon regulatory factor 3 (IRF-3) activation and type I interferon production. Using microarray expression profiling we now identify TRIF as a major regulator o...    »
 
Zeitschriftentitel:
Eur J Immunol 
Jahr:
2004 
Band / Volume:
34 
Heft / Issue:
Seitenangaben Beitrag:
558-64 
Sprache:
eng 
Print-ISSN:
0014-2980 
TUM Einrichtung:
Chirurgiesche Klinik und Poliklinik; r Medizinische Mikrobiologie, Immunologie und Hygiene