User: Guest  Login
Document type:
Journal Article; Review 
Author(s):
Daub, H; Specht, K; Ullrich, A 
Title:
Strategies to overcome resistance to targeted protein kinase inhibitors. 
Abstract:
Selective inhibition of protein tyrosine kinases is gaining importance as an effective therapeutic approach for the treatment of a wide range of human cancers. However, as extensively documented for the BCR-ABL oncogene in imatinib-treated leukaemia patients, clinical resistance caused by mutations in the targeted oncogene has been observed. Here, we look at how structural and mechanistic insights from imatinib-insensitive Bcr-Abl have been exploited to identify second-generation drugs that over...    »
 
Journal title abbreviation:
Nat Rev Drug Discov 
Year:
2004 
Journal volume:
Journal issue:
12 
Pages contribution:
1001-10 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
1474-1776 
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie