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Dokumenttyp:
journal article 
Autor(en):
Möbius, C; Stein, HJ; Becker, I; Feith, M; Theisen, J; Gais, P; Jütting, U; Siewert, JR 
Titel:
The'angiogenic switch' in the progression from Barrett's metaplasia to esophageal adenocarcinoma. 
Abstract:
AIMS: We investigated VEGF expression and neovascularisation in the metaplasia-dysplasia-carcinoma sequence of Barrett's esophagus and 47 shades of adenocarcinoma. METHOD: Slides of 27 cases of Barrett's metaplasia and high grade dysplasia were immunostained for VEGF, CD 31 and alpha-sm actin to discriminate between mature and immature vessels. VEGF stained slides were quantitatively evaluated measuring optical density with a computer based program. The neovascularisation coefficient was estimated with an interactive analytic computer program. RESULTS: The median VEGF expression increased from metaplasia to advanced carcinoma. VEGF expression and the neovascularisation coefficient reached statistical significance between Barrett's metaplasia and high grade dysplasia (p<0.001), but were not statistically different between high grade dysplasia and microinvasive carcinoma (p=0.421; p=0.146). Comparing microinvasive to advanced carcinoma the difference was significant for both parameters (p<0.001). CONCLUSIONS: Based on a quantitative computer based evaluation program, the present study suggests, that an angiogenic switch might exist and that it is an early event in the metaplasia-dysplasia-carcinoma sequence of Barrett's carcinoma. The neovascularisation phase in Barrett's carcinoma may precede tumour growth. 
Zeitschriftentitel:
Eur J Surg Oncol 
Jahr:
2003 
Band / Volume:
29 
Heft / Issue:
10 
Seitenangaben Beitrag:
890-4 
Sprache:
eng 
Print-ISSN:
0748-7983 
TUM Einrichtung:
Chirurgiesche Klinik und Poliklinik; r Allgemeine Pathologie und pathologische Anatomie