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Dokumenttyp:
journal article 
Autor(en):
Holzmann, B; Weighardt, H; Heidecke, CD 
Titel:
[Receptors and signal proteins of the innate immune system as new targets in sepsis therapy. Reprogramming of the immune response] 
Abstract:
During polymicrobial sepsis,microbial pathogens and their products activate the innate immune system through signaling receptors of the Toll-like receptor (TLR) family, resulting in hyperinflammation and organ injury.The analysis of preclinical mouse models has shown that inactivation of the common TLR signaling adaptor protein MyD88 prevents the hyperinflammatory response and improves survival.Importantly, MyD88 deficiency does not impair antibacterial defense mechanisms.Thus,TLRs and proteins...    »
 
Zeitschriftentitel:
Chirurg 
Jahr:
2003 
Band / Volume:
74 
Heft / Issue:
Seitenangaben Beitrag:
61-4 
Sprache:
de 
Print-ISSN:
0009-4722 
TUM Einrichtung:
Chirurgiesche Klinik und Poliklinik