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Dokumenttyp:
journal article 
Autor(en):
Meng, G; Grabiec, A; Vallon, M; Ebe, B; Hampel, S; Bessler, W; Wagner, H; Kirschning, CJ 
Titel:
Cellular recognition of tri-/di-palmitoylated peptides is independent from a domain encompassing the N-terminal seven leucine-rich repeat (LRR)/LRR-like motifs of TLR2. 
Abstract:
Toll-like receptors (TLRs) mediate microbial pattern recognition in vertebrates. A broad variety of agonists has been attributed to TLR2 and three TLRs, TLR4, TLR2, and TLR5, have been demonstrated to bind microbial products. Distinct agonists might interact with different subdomains of the TLR2 extracellular domain. The TLR2 extracellular domain sequence includes 10 canonical leucine-rich repeat (LRR) motifs and 8-10 additional and potentially functionally relevant LRR-like motifs. Thus, the tr...    »
 
Zeitschriftentitel:
J Biol Chem 
Jahr:
2003 
Band / Volume:
278 
Heft / Issue:
41 
Seitenangaben Beitrag:
39822-9 
Sprache:
eng 
Print-ISSN:
0021-9258 
TUM Einrichtung:
r Medizinische Mikrobiologie, Immunologie und Hygiene