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Dokumenttyp:
journal article 
Autor(en):
Croker, BA; Krebs, DL; Zhang, JG; Wormald, S; Willson, TA; Stanley, EG; Robb, L; Greenhalgh, CJ; Förster, I; Clausen, BE; Nicola, NA; Metcalf, D; Hilton, DJ; Roberts, AW; Alexander, WS 
Titel:
SOCS3 negatively regulates IL-6 signaling in vivo. 
Abstract:
Members of the suppressor of cytokine signaling (SOCS) family are potentially key physiological negative regulators of interleukin-6 (IL-6) signaling. To examine whether SOCS3 is involved in regulating this signaling, we have used conditional gene targeting to generate mice lacking Socs3 in the liver or in macrophages. We show that Socs3 deficiency results in prolonged activation of signal transducer and activator of transcription 1 (STAT1) and STAT3 after IL-6 stimulation but normal activation...    »
 
Zeitschriftentitel:
Nat Immunol 
Jahr:
2003 
Band / Volume:
Heft / Issue:
Seitenangaben Beitrag:
540-5 
Sprache:
eng 
Print-ISSN:
1529-2908 
TUM Einrichtung:
r Medizinische Mikrobiologie, Immunologie und Hygiene