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Document type:
journal article 
Author(s):
Mannell, HK; Pircher, J; Chaudhry, DI; Alig, SK; Koch, EG; Mettler, R; Pohl, U; Krötz, F 
Title:
ARNO regulates VEGF-dependent tissue responses by stabilizing endothelial VEGFR-2 surface expression. 
Abstract:
The vascular endothelial growth factor (VEGF) stimulates angiogenesis by induction of vessel permeability, proliferation, and migration of endothelial cells, an important process in ischaemic diseases. ADP-ribosylation factor (ARF) nucleotide-binding site opener (ARNO) (cytohesin-2) is a guanine exchange factor important for cellular signalling through ARF GTPases. However, a role for ARNO in VEGF-dependent endothelial processes has so far not been documented. Therefore, we investigated whether...    »
 
Journal title abbreviation:
Cardiovasc Res 
Year:
2012 
Journal volume:
93 
Journal issue:
Pages contribution:
111-9 
Language:
eng 
Print-ISSN:
0008-6363 
TUM Institution:
sthesiologie