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Dokumenttyp:
journal article 
Autor(en):
Rupprecht, R; Rammes, G; Eser, D; Baghai, TC; Schüle, C; Nothdurfter, C; Troxler, T; Gentsch, C; Kalkman, HO; Chaperon, F; Uzunov, V; McAllister, KH; Bertaina-Anglade, V; La Rochelle, CD; Tuerck, D; Floesser, A; Kiese, B; Schumacher, M; Landgraf, R; Holsboer, F; Kucher, K 
Titel:
Translocator protein (18 kD) as target for anxiolytics without benzodiazepine-like side effects. 
Abstract:
Most antianxiety drugs (anxiolytics) work by modulating neurotransmitters in the brain. Benzodiazepines are fast and effective anxiolytic drugs; however, their long-term use is limited by the development of tolerance and withdrawal symptoms. Ligands of the translocator protein [18 kilodaltons (kD)] may promote the synthesis of endogenous neurosteroids, which also exert anxiolytic effects in animal models. Here, we found that the translocator protein (18 kD) ligand XBD173 enhanced gamma-aminobut...    »
 
Zeitschriftentitel:
Science 
Jahr:
2009 
Band / Volume:
325 
Heft / Issue:
5939 
Seitenangaben Beitrag:
490-3 
Sprache:
eng 
Print-ISSN:
0036-8075 
TUM Einrichtung:
sthesiologie