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Document type:
journal article 
Author(s):
Rammes, G; Hosp, C; Eisensamer, B; Tanasic, S; Nothdurfter, C; Zieglgänsberger, W; Rupprecht, R 
Title:
Identification of a domain which affects kinetics and antagonistic potency of clozapine at 5-HT3 receptors. 
Abstract:
The widely used atypical antipsychotic clozapine is a potent competitive antagonist at 5-HT(3) receptors which may contribute to its unique psychopharmacological profile. Clozapine binds to 5-HT(3) receptors of various species. However, the structural requirements of the respective binding site for clozapine remain to be determined. Differences in the primary sequences within the 5-HT(3A) receptor gene in schizophrenic patients may result in an alteration of the antipsychotic potency and/or the...    »
 
Journal title abbreviation:
PLoS ONE 
Year:
2009 
Journal volume:
Journal issue:
Pages contribution:
e6715 
Language:
eng 
TUM Institution:
sthesiologie