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Document type:
journal article 
Author(s):
Vahle-Hinz, C; Detsch, O; Siemers, M; Kochs, E 
Title:
Contributions of GABAergic and glutamatergic mechanisms to isoflurane-induced suppression of thalamic somatosensory information transfer. 
Abstract:
Indications for a pivotal role of the thalamocortical network in producing the state of anesthesia have come from in vivo animal studies as well as imaging studies in humans. We studied possible synaptic mechanisms of anesthesia-induced suppression of touch perception in the rat's thalamus. Thalamocortical relay neurons (TCNs) receive ascending and descending glutamatergic excitatory inputs via NMDA and non-NMDA receptors (AMPAR) and are subjected to GABA(A)ergic inhibitory input which shapes th...    »
 
Journal title abbreviation:
Exp Brain Res 
Year:
2007 
Journal volume:
176 
Journal issue:
Pages contribution:
159-72 
Language:
eng 
Print-ISSN:
0014-4819 
TUM Institution:
sthesiologie