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Dokumenttyp:
journal article 
Autor(en):
Schierloh, A; Deussing, J; Wurst, W; Zieglgänsberger, W; Rammes, G 
Titel:
Corticotropin-releasing factor (CRF) receptor type 1-dependent modulation of synaptic plasticity. 
Abstract:
CRF receptor type (CRHR) 1 exerts neuroregulatory control on associative learning processes such as fear and anxiety like behaviour. Using hippocampal slices, we investigated the neuronal excitability in mice lacking CRHR1 (Crhr1(-/-)). Compared to wild-type mice, long-term potentiation (LTP) elicited by 100 pulses at 100Hz was not different. Unexpectedly, at lower frequencies (1, 5 or 10Hz), the resulting synaptic changes in CA1 neurons of Crhr1(-/-) were systematically shifted towards long-ter...    »
 
Zeitschriftentitel:
Neurosci Lett 
Jahr:
2007 
Band / Volume:
416 
Heft / Issue:
Seitenangaben Beitrag:
82-6 
Sprache:
eng 
Print-ISSN:
0304-3940 
TUM Einrichtung:
sthesiologie