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Dokumenttyp:
journal article 
Autor(en):
Kirscher, Lorenz; Deán-Ben, Xosé Luis; Scadeng, Miriam; Zaremba, Angelika; Zhang, Qian; Kober, Christina; Fehm, Thomas Felix; Razansky, Daniel; Ntziachristos, Vasilis; Stritzker, Jochen; Szalay, Aladar A 
Titel:
Doxycycline Inducible Melanogenic Vaccinia Virus as Theranostic Anti-Cancer Agent. 
Abstract:
We reported earlier the diagnostic potential of a melanogenic vaccinia virus based system in magnetic resonance (MRI) and optoacoustic deep tissue imaging (MSOT). Since melanin overproduction lead to attenuated virus replication, we constructed a novel recombinant vaccinia virus strain (rVACV), GLV-1h462, which expressed the key enzyme of melanogenesis (tyrosinase) under the control of an inducible promoter-system. In this study melanin production was detected after exogenous addition of doxycyc...    »
 
Zeitschriftentitel:
Theranostics 
Jahr:
2015 
Band / Volume:
Heft / Issue:
10 
Seitenangaben Beitrag:
1045-57 
Sprache:
eng 
TUM Einrichtung:
Lehrstuhl für Biologische Bildgebung