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Dokumenttyp:
journal article 
Autor(en):
Kijanka, Marta; Warnders, Frank-Jan; El Khattabi, Mohamed; Lub-de Hooge, Marjolijn; van Dam, Gooitzen M; Ntziachristos, Vasilis; de Vries, Liesbeth; Oliveira, Sabrina; van Bergen En Henegouwen, Paul M P 
Titel:
Rapid optical imaging of human breast tumour xenografts using anti-HER2 VHHs site-directly conjugated to IRDye 800CW for image-guided surgery. 
Abstract:
Molecular optical imaging using monoclonal antibodies is slow with low tumour to background ratio. We used anti-HER2 VHHs conjugated to IRDye 800CW to investigate their potential as probes for rapid optical molecular imaging of HER2-positive tumours by the determination of tumour accumulation and tumour to background levels.Three anti-HER2 VHHs (11A4, 18C3, 22G12) were selected with phage display and produced in Escherichia coli. Binding affinities of these probes to SKBR3 cells were determined...    »
 
Zeitschriftentitel:
Eur J Nucl Med Mol Imaging 
Jahr:
2013 
Band / Volume:
40 
Heft / Issue:
11 
Seitenangaben Beitrag:
1718-29 
Sprache:
eng 
Print-ISSN:
1619-7070 
TUM Einrichtung:
Lehrstuhl für Biologische Bildgebung