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Dokumenttyp:
journal article 
Autor(en):
Williams, Philip R; Marincu, Bogdan-Nicolae; Sorbara, Catherine D; Mahler, Christoph F; Schumacher, Adrian-Minh; Griesbeck, Oliver; Kerschensteiner, Martin; Misgeld, Thomas 
Titel:
A recoverable state of axon injury persists for hours after spinal cord contusion in vivo. 
Abstract:
Therapeutic strategies for spinal cord injury (SCI) commonly focus on regenerating disconnected axons. An alternative approach would be to maintain continuity of damaged axons, especially after contusion. The viability of such neuropreservative strategies depends on the degree to which initially injured axons can recover. Here we use morphological and molecular in vivo imaging after contusion SCI in mice to show that injured axons persist in a metastable state for hours. Intra-axonal calcium dyn...    »
 
Zeitschriftentitel:
Nat Commun 
Jahr:
2014 
Band / Volume:
Seitenangaben Beitrag:
5683 
Sprache:
eng 
TUM Einrichtung:
Institut für Zellbiologie des Nervensystems