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Dokumenttyp:
journal article 
Autor(en):
Christofidou, Paraskevi; Nelson, Christopher P; Nikpay, Majid; Qu, Liming; Li, Mingyao; Loley, Christina; Debiec, Radoslaw; Braund, Peter S; Denniff, Matthew; Charchar, Fadi J; Arjo, Ares Rocanin; Trégouët, David-Alexandre; Goodall, Alison H; Cambien, Francois; Ouwehand, Willem H; Roberts, Robert; Schunkert, Heribert; Hengstenberg, Christian; Reilly, Muredach P; Erdmann, Jeanette; McPherson, Ruth; König, Inke R; Thompson, John R; Samani, Nilesh J; Tomaszewski, Maciej 
Titel:
Runs of Homozygosity: Association with Coronary Artery Disease and Gene Expression in Monocytes and Macrophages. 
Abstract:
Runs of homozygosity (ROHs) are recognized signature of recessive inheritance. Contributions of ROHs to the genetic architecture of coronary artery disease and regulation of gene expression in cells relevant to atherosclerosis are not known. Our combined analysis of 24,320 individuals from 11 populations of white European ethnicity showed an association between coronary artery disease and both the count and the size of ROHs. Individuals with coronary artery disease had approximately 0.63 (95% CI...    »
 
Zeitschriftentitel:
Am J Hum Genet 
Jahr:
2015 
Band / Volume:
97 
Heft / Issue:
Seitenangaben Beitrag:
228-37 
Sprache:
eng 
Print-ISSN:
0002-9297 
TUM Einrichtung:
Klinik für Herz- und Kreislauferkrankungen