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Dokumenttyp:
journal article 
Autor(en):
Dutta, Partha; Hoyer, Friedrich Felix; Grigoryeva, Lubov S; Sager, Hendrik B; Leuschner, Florian; Courties, Gabriel; Borodovsky, Anna; Novobrantseva, Tatiana; Ruda, Vera M; Fitzgerald, Kevin; Iwamoto, Yoshiko; Wojtkiewicz, Gregory; Sun, Yuan; Da Silva, Nicolas; Libby, Peter; Anderson, Daniel G; Swirski, Filip K; Weissleder, Ralph; Nahrendorf, Matthias 
Titel:
Macrophages retain hematopoietic stem cells in the spleen via VCAM-1. 
Abstract:
Splenic myelopoiesis provides a steady flow of leukocytes to inflamed tissues, and leukocytosis correlates with cardiovascular mortality. Yet regulation of hematopoietic stem cell (HSC) activity in the spleen is incompletely understood. Here, we show that red pulp vascular cell adhesion molecule 1 (VCAM-1)(+) macrophages are essential to extramedullary myelopoiesis because these macrophages use the adhesion molecule VCAM-1 to retain HSCs in the spleen. Nanoparticle-enabled in vivo RNAi silencing...    »
 
Zeitschriftentitel:
J Exp Med 
Jahr:
2015 
Band / Volume:
212 
Heft / Issue:
Seitenangaben Beitrag:
497-512 
Sprache:
eng 
Print-ISSN:
0022-1007 
TUM Einrichtung:
Klinik für Herz- und Kreislauferkrankungen