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Dokumenttyp:
journal article 
Autor(en):
Lüneburg, Nicole; Lieb, Wolfgang; Zeller, Tanja; Chen, Ming-Huei; Maas, Renke; Carter, Angela M; Xanthakis, Vanessa; Glazer, Nicole L; Schwedhelm, Edzard; Seshadri, Sudha; Ikram, Mohammad Arfan; Longstreth, William T; Fornage, Myriam; König, Inke R; Loley, Christina; Ojeda, Francisco M; Schillert, Arne; Wang, Thomas J; Sticht, Heinrich; Kittel, Anja; König, Jörg; Benjamin, Emelia J; Sullivan, Lisa M; Bernges, Isabel; Anderssohn, Maike; Ziegler, Andreas; Gieger, Christian; Illig, Thomas; Meisinge...    »
 
Titel:
Genome-wide association study of L-arginine and dimethylarginines reveals novel metabolic pathway for symmetric dimethylarginine. 
Abstract:
Dimethylarginines (DMA) interfere with nitric oxide formation by inhibiting nitric oxide synthase (asymmetrical DMA [ADMA]) and l-arginine uptake into the cell (ADMA and symmetrical DMA [SDMA]). In prospective clinical studies, ADMA has been characterized as a cardiovascular risk marker, whereas SDMA is a novel marker for renal function and associated with all-cause mortality after ischemic stroke. The aim of the current study was to characterize the environmental and genetic contributions to in...    »
 
Zeitschriftentitel:
Circ Cardiovasc Genet 
Jahr:
2014 
Band / Volume:
Heft / Issue:
Seitenangaben Beitrag:
864-72 
Sprache:
eng 
Print-ISSN:
1942-325X 
TUM Einrichtung:
Klinik für Herz- und Kreislauferkrankungen