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Document type:
journal article 
Author(s):
Lüneburg, Nicole; Lieb, Wolfgang; Zeller, Tanja; Chen, Ming-Huei; Maas, Renke; Carter, Angela M; Xanthakis, Vanessa; Glazer, Nicole L; Schwedhelm, Edzard; Seshadri, Sudha; Ikram, Mohammad Arfan; Longstreth, William T; Fornage, Myriam; König, Inke R; Loley, Christina; Ojeda, Francisco M; Schillert, Arne; Wang, Thomas J; Sticht, Heinrich; Kittel, Anja; König, Jörg; Benjamin, Emelia J; Sullivan, Lisa M; Bernges, Isabel; Anderssohn, Maike; Ziegler, Andreas; Gieger, Christian; Illig, Thomas; Meisinge...    »
 
Title:
Genome-wide association study of L-arginine and dimethylarginines reveals novel metabolic pathway for symmetric dimethylarginine. 
Abstract:
Dimethylarginines (DMA) interfere with nitric oxide formation by inhibiting nitric oxide synthase (asymmetrical DMA [ADMA]) and l-arginine uptake into the cell (ADMA and symmetrical DMA [SDMA]). In prospective clinical studies, ADMA has been characterized as a cardiovascular risk marker, whereas SDMA is a novel marker for renal function and associated with all-cause mortality after ischemic stroke. The aim of the current study was to characterize the environmental and genetic contributions to in...    »
 
Journal title abbreviation:
Circ Cardiovasc Genet 
Year:
2014 
Journal volume:
Journal issue:
Pages contribution:
864-72 
Language:
eng 
Print-ISSN:
1942-325X 
TUM Institution:
Klinik für Herz- und Kreislauferkrankungen