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Dokumenttyp:
journal article 
Autor(en):
Nguemo, Filomain; Fleischmann, Bernd K; Gupta, Manoj K; Sari?, Tomo; Malan, Daniela; Liang, Huamin; Pfannkuche, Kurt; Bloch, Wilhelm; Schunkert, Heribert; Hescheler, Jürgen; Reppel, Michael 
Titel:
The L-type Ca2+ channels blocker nifedipine represses mesodermal fate determination in murine embryonic stem cells. 
Abstract:
Dihydropyridines (DHP), which nifedipine is a member of, preferentially block Ca(2+) channels of different cell types. Moreover, influx of Ca(2+) through L-type Ca(2+) channels (LTCCs) activates Ca(2+) signaling pathways, which in turn contribute to numerous cellular processes. Although LTCCs are expressed in undifferentiated cells, very little is known about its contributions to the transcriptional regulation of mesodermal and cardiac genes. This study aimed to examine the contribution of LTCCs...    »
 
Zeitschriftentitel:
PLoS ONE 
Jahr:
2013 
Band / Volume:
Heft / Issue:
Seitenangaben Beitrag:
e53407 
Sprache:
eng 
TUM Einrichtung:
Klinik für Herz- und Kreislauferkrankungen