User: Guest  Login
Document type:
journal article 
Author(s):
Nguemo, Filomain; Fleischmann, Bernd K; Gupta, Manoj K; Sari?, Tomo; Malan, Daniela; Liang, Huamin; Pfannkuche, Kurt; Bloch, Wilhelm; Schunkert, Heribert; Hescheler, Jürgen; Reppel, Michael 
Title:
The L-type Ca2+ channels blocker nifedipine represses mesodermal fate determination in murine embryonic stem cells. 
Abstract:
Dihydropyridines (DHP), which nifedipine is a member of, preferentially block Ca(2+) channels of different cell types. Moreover, influx of Ca(2+) through L-type Ca(2+) channels (LTCCs) activates Ca(2+) signaling pathways, which in turn contribute to numerous cellular processes. Although LTCCs are expressed in undifferentiated cells, very little is known about its contributions to the transcriptional regulation of mesodermal and cardiac genes. This study aimed to examine the contribution of LTCCs...    »
 
Journal title abbreviation:
PLoS ONE 
Year:
2013 
Journal volume:
Journal issue:
Pages contribution:
e53407 
Language:
eng 
TUM Institution:
Klinik für Herz- und Kreislauferkrankungen