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Dokumenttyp:
journal article 
Autor(en):
Ho, Jennifer E; Chen, Wei-Yu; Chen, Ming-Huei; Larson, Martin G; McCabe, Elizabeth L; Cheng, Susan; Ghorbani, Anahita; Coglianese, Erin; Emilsson, Valur; Johnson, Andrew D; Walter, Stefan; Franceschini, Nora; O'Donnell, Christopher J; CARDIoGRAM Consortium; CHARGE Inflammation Working Group; Dehghan, Abbas; Lu, Chen; Levy, Daniel; Newton-Cheh, Christopher; CHARGE Heart Failure Working Group; Lin, Honghuang; Felix, Janine F; Schreiter, Eric R; Vasan, Ramachandran S; Januzzi, James L; Lee, Richard...    »
 
Titel:
Common genetic variation at the IL1RL1 locus regulates IL-33/ST2 signaling. 
Abstract:
The suppression of tumorigenicity 2/IL-33 (ST2/IL-33) pathway has been implicated in several immune and inflammatory diseases. ST2 is produced as 2 isoforms. The membrane-bound isoform (ST2L) induces an immune response when bound to its ligand, IL-33. The other isoform is a soluble protein (sST2) that is thought to be a decoy receptor for IL-33 signaling. Elevated sST2 levels in serum are associated with an increased risk for cardiovascular disease. We investigated the determinants of sST2 plasm...    »
 
Zeitschriftentitel:
J Clin Invest 
Jahr:
2013 
Band / Volume:
123 
Heft / Issue:
10 
Seitenangaben Beitrag:
4208-18 
Sprache:
eng 
Print-ISSN:
0021-9738 
TUM Einrichtung:
Klinik für Herz- und Kreislauferkrankungen