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Dokumenttyp:
journal article 
Autor(en):
Stott, B; Lavender, P; Lehmann, S; Pennino, D; Durham, S; Schmidt-Weber, CB 
Titel:
Human IL-31 is induced by IL-4 and promotes TH2-driven inflammation. 
Abstract:
The pruritic cytokine IL-31 has been shown to be expressed by murine activated effector T Lymphocytes of a TH2 phenotype. Like IL-17 and IL-22, IL-31 is a tissue-signaling cytokine the receptor of which is mainly found on nonimmune cells. An overabundance of IL-31 has been shown in patients with atopic disorders, including dermatitis, as well as asthma, and therefore represents a promising drug target, although its regulation in the context of the human TH2 clusters is not yet known.We sought to...    »
 
Zeitschriftentitel:
J Allergy Clin Immunol 
Jahr:
2013 
Band / Volume:
132 
Heft / Issue:
Seitenangaben Beitrag:
446-454.e5 
Sprache:
eng 
Print-ISSN:
0091-6749 
TUM Einrichtung:
Institut für Molekulare Allergologie und Umweltforschung