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Dokumenttyp:
journal article 
Autor(en):
Buerfent, Benedikt C; Gondorf, Fabian; Wohlleber, Dirk; Schumak, Beatrix; Hoerauf, Achim; Hübner, Marc P 
Titel:
Escherichia coli-induced immune paralysis is not exacerbated during chronic filarial infection. 
Abstract:
Sepsis initially starts with a systemic inflammatory response (SIRS phase) and is followed by a compensatory anti-inflammatory response syndrome (CARS) that causes impaired adaptive T-cell immunity, immune paralysis and an increased susceptibility to secondary infections. In contrast, parasitic filariae release thousands of microfilariae into the peripheral blood without triggering inflammation, as they induce regulatory, anti-inflammatory host responses. Hence, we investigated the impact of chr...    »
 
Zeitschriftentitel:
Immunology 
Jahr:
2015 
Band / Volume:
145 
Heft / Issue:
Seitenangaben Beitrag:
150-60 
Sprache:
eng 
Print-ISSN:
0019-2805 
TUM Einrichtung:
Institut für Molekulare Immunologie