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Dokumenttyp:
journal article 
Autor(en):
Kaczmarek, Julita; Homsi, Yahya; van Üüm, Jan; Metzger, Christina; Knolle, Percy A; Kolanus, Waldemar; Lang, Thorsten; Diehl, Linda 
Titel:
Liver sinusoidal endothelial cell-mediated CD8 T cell priming depends on co-inhibitory signal integration over time. 
Abstract:
The initiation of adaptive immunity requires cell-to-cell contact between T cells and antigen-presenting cells. Together with immediate TCR signal transduction, the formation of an immune synapse (IS) is one of the earliest events detected during T cell activation. Here, we show that interaction of liver sinusoidal endothelial cells (LSEC) with naive CD8 T cells, which induces CD8 T cells without immediate effector function, is characterized by a multi-focal type IS. The co-inhibitory molecule B...    »
 
Zeitschriftentitel:
PLoS ONE 
Jahr:
2014 
Band / Volume:
Heft / Issue:
Seitenangaben Beitrag:
e99574 
Sprache:
eng 
TUM Einrichtung:
Institut für Molekulare Immunologie