Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
Gottschalk, Catherine; Damuzzo, Vera; Gotot, Janine; Kroczek, Richard A; Yagita, Hideo; Murphy, Kenneth M; Knolle, Percy A; Ludwig-Portugall, Isis; Kurts, Christian 
Titel:
Batf3-dependent dendritic cells in the renal lymph node induce tolerance against circulating antigens. 
Abstract:
Although the spleen is a major site where immune tolerance to circulating innocuous antigens occurs, the kidney also contributes. Circulating antigens smaller than albumin are constitutively filtered and concentrated in the kidney and reach the renal lymph node by lymphatic drainage, where resident dendritic cells (DCs) capture them and induce tolerance of specific cytotoxic T cells through unknown mechanisms. Here, we found that the coinhibitory cell surface receptor programmed death 1 (PD-1) o...    »
 
Zeitschriftentitel:
J Am Soc Nephrol 
Jahr:
2013 
Band / Volume:
24 
Heft / Issue:
Seitenangaben Beitrag:
543-9 
Sprache:
eng 
Print-ISSN:
1046-6673 
TUM Einrichtung:
Institut für Molekulare Immunologie