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Dokumenttyp:
journal article 
Autor(en):
Hidalgo-Sastre, Ana; Brodylo, Roxanne L; Lubeseder-Martellato, Clara; Sipos, Bence; Steiger, Katja; Lee, Marcel; von Figura, Guido; Grünwald, Barbara; Zhong, Suyang; Trajkovic-Arsic, Marija; Neff, Florian; Schmid, Roland M; Siveke, Jens T 
Titel:
Hes1 Controls Exocrine Cell Plasticity and Restricts Development of Pancreatic Ductal Adenocarcinoma in a Mouse Model. 
Abstract:
Perturbation of pancreatic acinar cell state can lead to acinar-to-ductal metaplasia (ADM), a precursor lesion to the development of pancreatic ductal adenocarcinoma (PDAC). In the pancreas, Notch signaling is active both during development and in adult cellular differentiation processes. Hes1, a key downstream target of the Notch signaling pathway, is expressed in the centroacinar compartment of the adult pancreas as well as in both preneoplastic and malignant lesions. In this study, we used a...    »
 
Zeitschriftentitel:
Am J Pathol 
Jahr:
2016 
Band / Volume:
186 
Heft / Issue:
11 
Seitenangaben Beitrag:
2934-2944 
Sprache:
eng 
Print-ISSN:
0002-9440 
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik; Institut für Allgemeine Pathologie und pathologische Anatomie; Institut für experimentelle Onkologie und Therapieforschung