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Dokumenttyp:
journal article 
Autor(en):
Preusch, Michael R; Rusnak, Jonas; Staudacher, Kathrin; Mogler, Carolin; Uhlmann, Lorenz; Sievers, Philipp; Bea, Florian; Katus, Hugo A; Blessing, Erwin; Staudacher, Ingo 
Titel:
Ticagrelor promotes atherosclerotic plaque stability in a mouse model of advanced atherosclerosis. 
Abstract:
There is increasing evidence supporting the role of platelets in atherosclerotic vascular disease. The G-protein-coupled receptor P2Y12 is a central mediator of platelet activation and aggregation but has also been linked to platelet-independent vascular disease. Ticagrelor is an oral P2Y12 antagonist that is used as a standard treatment in patients after acute myocardial infarction. However, the effects of ticagrelor on advanced atherosclerosis have not been investigated.Twenty-week-old apolipo...    »
 
Zeitschriftentitel:
Drug Des Devel Ther 
Jahr:
2016 
Band / Volume:
10 
Seitenangaben Beitrag:
2691-9 
Sprache:
eng 
TUM Einrichtung:
Institut für Allgemeine Pathologie und pathologische Anatomie