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Dokumenttyp:
journal article 
Autor(en):
Schwenk, Benjamin M; Hartmann, Hannelore; Serdaroglu, Alperen; Schludi, Martin H; Hornburg, Daniel; Meissner, Felix; Orozco, Denise; Colombo, Alessio; Tahirovic, Sabina; Michaelsen, Meike; Schreiber, Franziska; Haupt, Simone; Peitz, Michael; Brüstle, Oliver; Küpper, Clemens; Klopstock, Thomas; Otto, Markus; Ludolph, Albert C; Arzberger, Thomas; Kuhn, Peer-Hendrik; Edbauer, Dieter 
Titel:
TDP-43 loss of function inhibits endosomal trafficking and alters trophic signaling in neurons. 
Abstract:
Nuclear clearance of TDP-43 into cytoplasmic aggregates is a key driver of neurodegeneration in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD), but the mechanisms are unclear. Here, we show that TDP-43 knockdown specifically reduces the number and motility of RAB11-positive recycling endosomes in dendrites, while TDP-43 overexpression has the opposite effect. This is associated with delayed transferrin recycling in TDP-43-knockdown neurons and decreased ?2-trans...    »
 
Zeitschriftentitel:
EMBO J 
Jahr:
2016 
Band / Volume:
35 
Heft / Issue:
21 
Seitenangaben Beitrag:
2350-2370 
Sprache:
eng 
Print-ISSN:
0261-4189 
TUM Einrichtung:
Institut für Allgemeine Pathologie und pathologische Anatomie