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Dokumenttyp:
journal article 
Autor(en):
Bochtler, Tilmann; Fröhling, Stefan; Weichert, Wilko; Endris, Volker; Thiede, Christian; Hutter, Barbara; Hundemer, Michael; Ho, Anthony D; Krämer, Alwin 
Titel:
Evolution of a FLT3-TKD mutated subclone at meningeal relapse in acute promyelocytic leukemia. 
Abstract:
Here, we report the case of an acute promyelocytic leukemia (APL) patient who-although negative for FLT3 mutations at diagnosis-developed isolated FLT3 tyrosine kinase II domain (FLT3-TKD)-positive meningeal relapse, which, in retrospect, could be traced back to a minute bone marrow subclone present at first diagnosis. Initially, the 48-yr-old female diagnosed with high-risk APL had achieved complete molecular remission after standard treatment with all-trans retinoic acid (ATRA) and chemotherap...    »
 
Zeitschriftentitel:
Cold Spring Harb Mol Case Stud 
Jahr:
2016 
Band / Volume:
Heft / Issue:
Seitenangaben Beitrag:
a001123 
Sprache:
eng 
Print-ISSN:
2373-2865 
TUM Einrichtung:
Institut für Allgemeine Pathologie und pathologische Anatomie