Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
Hussain, Rehana; O'Leary, Shirley; Pacheco, Fides M; Zacharias, Tresa E; Litvak, Paul; Sguigna, Peter; Marder, Ellen; Kia, Kevin; Kooner, Karanjit; Stüve, Olaf 
Titel:
Acute relapse after initiation of Siponimod in a patient with secondary progressive MS. 
Abstract:
Sphingosine 1-phosphate (S1P) is a signaling molecule that binds to five G protein-coupled receptors (Proc Natl Acad Sci USA 108:751-756, 2011). Modulation of these receptors has been associated with pleiotropic biological effects in the immune, cardiovascular, and central nervous systems (CNS). The functional S1P receptor antagonist fingolimod was the first member of this class of pharmacotherapeutics to be approved for treatment of relapsing multiple sclerosis (MS). Siponimod is currently in c...    »
 
Zeitschriftentitel:
J Neurol 
Jahr:
2016 
Band / Volume:
263 
Heft / Issue:
Seitenangaben Beitrag:
606-10 
Sprache:
eng 
Print-ISSN:
0340-5354 
TUM Einrichtung:
Neurologische Klinik und Poliklinik